Npgrj_Nn_1534 1310..1318
نویسندگان
چکیده
At many excitatory and inhibitory synapses throughout the nervous system, postsynaptic currents become faster as the synapse matures, primarily owing to changes in receptor subunit composition. The origin of the developmental acceleration of AMPA receptor (AMPAR)-mediated excitatory postsynaptic currents (EPSCs) remains elusive. We used patch-clamp recordings, electron microscopic immunogold localization of AMPARs, partial three-dimensional reconstruction of the neuropil and numerical simulations of glutamate diffusion and AMPAR activation to examine the factors underlying the developmental speeding of miniature EPSCs in mouse cerebellar granule cells. We found that the main developmental change that permits submillisecond transmission at mature synapses is an alteration in the glutamate concentration waveform as experienced by AMPARs. This can be accounted for by changes in the synaptic structure and surrounding neuropil, rather than by a change in AMPAR properties. Our findings raise the possibility that structural alterations could be a general mechanism underlying the change in the time course of AMPAR-mediated synaptic transmission.
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3 GlaxoSmithKline, King of Prussia, PA, 19406 8 9 *Corresponding author: 10 Department of Microbiology & Immunology, Dartmouth Medical School, Hanover, NH 11 03755 12 Phone: (603) 650-1310 Fax: (603) 650-1318 13 Email: [email protected] 14 15 16 17 Running Title: ClpPC degrades S. aureus antitoxins 18 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Insti...
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